1454620-41-7Relevant academic research and scientific papers
Iodinated cyanine dyes: a new class of sensitisers for use in NIR activated photodynamic therapy (PDT)
Atchison, Jordan,Kamila, Sukanta,Nesbitt, Heather,Logan, Kieran A.,Nicholas, Dean M,Fowley, Colin,Davis, James,Callan, Bridgeen,McHale, Anthony P,Callan, John F
, p. 2009 - 2012 (2017)
A new class of iodinated cyanine dyes have been prepared for use in NIR excited photodynamic therapy (PDT) and demonstrated improved efficacy in two pancreatic cell lines as well as excellent tumour control in a murine model of the disease.
Iodinated xanthene-cyanine NIR dyes as potential photosensitizers for antimicrobial photodynamic therapy
Ebaston, T. M.,Gellerman, Gary,Nakonechny, Faina,Patsenker, Leonid,Talalai, Efrosiniia
, (2020/10/02)
Photosensitizers (PSs) are chemical entities that upon light exposure are able to produce cytotoxic species such as singlet oxygen superoxide and free radicals. PSs are used in photodynamic therapy applications (PDT) to eradicate cancer cells, pathogenic bacteria, fungi, and viruses. Development of the NIR-activatable photosensitizes with high phototoxicity and low toxicity in dark conditions is challenging. Here we first report on the synthesis and antimicrobial testing of the new NIR photosensitizers based on the iodinated xanthene-cyanine dyes. These new photosensitizers exhibit high antimicrobial efficacy on Staphylococcus aureus pathogens at low dye concentration (~0.5 μM) and low NIR light dose (24.3 J/cm2).
Halogenated compounds for photodynamic therapy
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Page/Page column 104; 105, (2014/06/23)
Halo-organic heterocyclic compounds are described, which have the formulas Ring A is an aromatic ring bound to at least two halogen atoms, at least one of which is iodine or bromine. Also described are polymethine dyes based on these heterocyclic compound
