1454655-66-3

Basic information

• Product Name: C₄₂H₅₂N₁₂
• Synonyms: C₄₂H₅₂N₁₂
• CAS NO: 1454655-66-3
• Molecular Weight: 724.955
• Mol File: 1454655-66-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₄₂H₅₂N₁₂(CAS DataBase Reference)
• NIST Chemistry Reference: C₄₂H₅₂N₁₂(1454655-66-3)
• EPA Substance Registry System: C₄₂H₅₂N₁₂(1454655-66-3)

Safety Data

• Hazardous Substances Data: 1454655-66-3(Hazardous Substances Data)

Upstream product

• 104-16-5 3-(N-methylpiperazinyl)propyl chloride 
• 106-50-3 1,4-phenylenediamine 
• 1500081-63-9 A 
• 113705-27-4 2,7-diethynylnaphthalene 

Relevant articles and documents

Optimization of anti-proliferative activity using a screening approach with a series of bis-heterocyclic G-quadruplex ligands

Using a phenotypic screening and SAR optimization approach, a phenyl-bis-oxazole derivative has been identified with anti-proliferative activity, optimized with the use of a panel of cancer cell lines. The lead compound was synthesized by means of a short and effective two-step synthesis using Pd-catalyzed direct arylation. The compound stabilizes several quadruplex DNA sequences including a human telomeric DNA and one from the promoter of the HSP90 gene, although the structure-activity relationships of the series are not obviously related to the quadruplex binding.