1454659-75-6

Basic information

• Product Name: C₂₉H₃₇N₇O₆
• Synonyms: C₂₉H₃₇N₇O₆
• CAS NO: 1454659-75-6
• Molecular Weight: 579.656
• Mol File: 1454659-75-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₉H₃₇N₇O₆(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₉H₃₇N₇O₆(1454659-75-6)
• EPA Substance Registry System: C₂₉H₃₇N₇O₆(1454659-75-6)

Safety Data

• Hazardous Substances Data: 1454659-75-6(Hazardous Substances Data)

Upstream product

• 29022-11-5 N-(fluoren-9-ylmethoxycarbonyl)glycine 
• 35661-60-0 Fmoc-Leu-OH 
• 35661-40-6 N-Fmoc L-Phe 
• 71989-38-3 Fmoc-Tyr(tBu)-OH 

Relevant articles and documents

Systematic replacement of amides by 1,4-disubstituted[1,2,3]triazoles in Leu-enkephalin and the impact on the delta opioid receptor activity

Using Cu(I)-catalyzed azide-alkyne cycloaddition in a mixed classical organic phase and solid phase peptide synthesis approach, we synthesized four analogs of Leu-enkephalin to systematically replace amides by 1,4-disubstituted[1,2,3]triazoles. The peptidomimetics obtained were characterized by competitive binding, contractility assays and ERK1/2 phosphorylation. The present study reveals that the analog bearing a triazole between Phe and Leu retains some potency, more than all the others, suggesting that the hydrogen bond acceptor capacity of the last amide of Leu-enkephalin is essential for the biological activity of the peptide.