1454663-40-1

Basic information

• Product Name: C₁₅H₁₂ClN₃O₂
• CAS NO: 1454663-40-1
• Molecular Weight: 301.732
• Mol File: 1454663-40-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₁₅H₁₂ClN₃O₂(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₅H₁₂ClN₃O₂(1454663-40-1)
• EPA Substance Registry System: C₁₅H₁₂ClN₃O₂(1454663-40-1)

Safety Data

• Hazardous Substances Data: 1454663-40-1(Hazardous Substances Data)

Upstream product

• 273-09-6 benzofurazan 
• 32863-32-4 benzo[c][1,2,5]oxadiazole-4-carbaldehyde 
• 1454663-39-8 C₁₃H₁₀ClN₃O 
• 108-24-7 acetic anhydride 

Downstream Products

• 1454663-42-3 C₁₅H₁₁ClN₄O₄ 
• 1454663-41-2 C₁₅H₁₁ClN₄O₄ 
• 1454663-44-5 C₁₃H₉ClN₄O₃ 
• 1454663-43-4 C₁₃H₉ClN₄O₃ 

Relevant articles and documents

Identification, synthesis and evaluation of substituted benzofurazans as inhibitors of CREB-mediated gene transcription

Cyclic-AMP response-element binding protein (CREB) is a stimulus-activated transcription factor. Its transcription activity requires its binding with CREB-binding protein (CBP) after CREB is phosphorylated at Ser133. The domains involved for CREB-CBP interaction are kinase-inducible domain (KID) from CREB and KID-interacting domain (KIX) from CBP. Recent studies suggest that CREB is an attractive target for novel cancer therapeutics. To identify novel chemotypes as inhibitors of KIX-KID interaction, we screened the NCI-diversity set of compounds using a split renilla luciferase assay and identified 2-[(7-nitrobenzo[c][1,2,5]oxadiazol-4-yl)thio]pyridine 1-oxide (compound 1, NSC228155) as a potent inhibitor of KIX-KID interaction. However, compound 1 was not particularly selective against CREB-mediated gene transcription in living HEK 293T cells. Further structure-activityrelationship studies identified 4-aniline substituted nitrobenzofurazans with improved selectivity.