1454675-20-7

Upstream product

• 1374576-19-8 C₁₂H₁₈O₆ 
• 1374576-20-1 (1S,3S,5S)-8-[(tert-butyldimethylsilyl)oxy]-7-(ethoxycarbonyl)methyl-5-hydroxy-3-methoxy-2-oxabicyclo[3.3.0]oct-7-ene 
• 1374576-23-4 (1S,2R,4R,6S,8S)-2-[(tert-butyldimethylsilyl)oxy]-4-(ethoxycarbonyl)methyl-6-hydroxy-8-methoxy-9-oxatricyclo-[4.3.0(1,6).0(2,4)]nonane 
• 1374576-25-6 (1S,2R,4S,6S)-2-[(tert-butyldimethylsilyl)oxy]-4-[(ethoxycarbonyl)methyl]-6-trimethylsilyloxy-9-oxatricyclo-[4.3.0(1,6).0(2,4)]non-7-ene 
• 1374576-26-7 1-[(3'R,5'R,6'S)-3'-O-trimethylsilyl-5'-O-(tert-butyldimethylsilyl)-6'-[(ethoxycarbonyl)methyl]-2'-deoxy-2'-iodo-3',5'-ethano-5',6'-methano-β-D-ribofuranosyl]thymine 
• 1374576-27-8 1-[(3'S,5'R,6'S)-3'-O-trimethylsilyl-5'-O-(tert-butyldimethylsilyl)-6'-[(ethoxycarbonyl)methyl]-2'-deoxy-3',5'-ethano-5',6'-methano-β-D-ribofuranosyl]thymine 
• 1454675-19-4 C₃₃H₃₅N₃O₉ 
• 40615-36-9 4,4'-dimethoxytrityl chloride 
• 1374576-31-4 1-[(3'S,5'R,6'R)-5'-O-(tert-butyldimethylsilyl)-6'-(carboxymethyl)-2'-deoxy-3',5'-ethano-5',6'-methano-β-D-ribofuranosyl]thymine 
• 157887-82-6 9H-fluoren-9-ylmethyl N-(3-hydroxypropyl)carbamate 
• 1454675-18-3 C₃₉H₄₉N₃O₉Si 
• 65-71-4 thymin 

Downstream Products

• 1454675-21-8 C₆₃H₇₀N₅O₁₂P 

Relevant academic research and scientific papers

Tricyclic nucleosides and oligomeric compounds prepared therefrom

The present invention provides novel tricyclic nucleosides and oligomeric compounds prepared therefrom. Incorporation of one or more of the tricyclic nucleosides into an oligomeric compound is expected to enhance one or more properties of the oligomeric compound. Such oligomeric compounds can also be included in double stranded compositions. In certain embodiments, the oligomeric compounds provided herein are expected to hybridize to a portion of a target RNA resulting in loss of normal function of the target RNA.

TRICYCLIC NUCLEOSIDES AND OLIGOMERIC COMPOUNDS PREPARED THEREFROM

The present invention provides novel tricyclic nucleosides and oligomeric compounds prepared therefrom. Incorporation of one or more of the tricyclic nucleosides into an oligomeric compound is expected to enhance one or more properties of the oligomeric compound. Such oligomeric compounds can also be included in double stranded compositions. In certain embodiments, the oligomeric compounds provided herein are expected to hybridize to a portion of a target RNA resulting in loss of normal function of the target RNA.