1454782-75-2

Upstream product

• 477-48-5 (5aR,8aS,9R)-9-(3,4,5-trimethoxyphenyl)-5a,6,8a,9-tetrahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxole-5,8-dione 

Downstream Products

• 1454782-85-4 (5S,5aR,8aS,9R)-5-deutero-8-oxo-9-(3,4,5-trimethoxyphenyl)-5,5a,6,8,8a,9-hexahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol-5-yl propionate 
• 1454782-83-2 (5R,5aS,8aR,9R)-9-deuterio-5-(3,4,5-trimethoxyphenyl)-5,5a,8a,9-tetrahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxole-6(8H)-one 

Relevant academic research and scientific papers

PICROPODOPHYLLIN DERIVATIVES FOR USE IN THERAPY

The present invention is directed to new compounds of formula (I) wherein R1 is OH, H, D or -0-C(0)-C1C6 alkyl; R2 is H or D; R3 and R4 is each and independently H or D; and R5, R6 and R7 is each and independently H or D; with the exception of the compounds (5R,5aS,8aR,9R)-5,8,8a,9-Tetrahydro-9-hydroxy-5- (3,4,5-trimethoxyphenyl)-furo[3',4':6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one (picropodophyllin) and (5R)-5,8,8a,9-Tetrahydro-5-(3,4,5- trimethoxyphenyl)furo[3',4':6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one, [5R- (5. alpha., 5a. beta.,8a. alpha.)] (deoxypicropodophyllin). to a pharmaceutical composition comprising said compounds, and to the use of said compounds in therapy.