1454818-19-9Relevant academic research and scientific papers
Iodine mediated reaction of quinones and N-substituted amino esters to 2-substituted benzo[f]isoindole-4,9-diones
Li, Yu-Jin,Huang, Huan-Ming,Ju, Jie,Jia, Jian-Hong,Han, Liang,Ye, Qing,Yu, Wu-Bin,Gao, Jian-Rong
, p. 25840 - 25848 (2013/12/04)
A novel and efficient synthesis of benzo[f]isoindole-4,9-diones through the I2-promoted cyclization reaction of N-substituted amino acid esters and quinones has been realized successfully via an unprecedented 1,3-dipolar cycloaddition using KF as the base. Different substituted amino esters were found able to react with quinones through a cycloaddition reaction to afford 2-substituted benzo[f]isoindole-4,9-diones. The unexpected, short, attractive and direct synthesis of these interesting compounds is important and relevant, and provides an extremely preferable method for the synthesis of 2-substituted benzo[f]isoindole-4,9-diones.
