145485-31-0

Usage

Uses

Used in Pharmaceutical Research and Development:
7-IODO-1-TETRALONE is utilized as a key intermediate in the synthesis of various pharmaceuticals, leveraging its unique structural properties to contribute to the creation of novel drug candidates. Its potential applications in drug development are attributed to its ability to be modified and incorporated into complex molecular frameworks, facilitating the discovery of new therapeutic agents.
Used in Organic Synthesis:
In the field of organic chemistry, 7-IODO-1-TETRALONE serves as a versatile starting material for the synthesis of a range of organic compounds. Its reactivity and structural features make it an advantageous building block for the preparation of diverse chemical entities, thereby expanding the scope of organic synthesis and contributing to the discovery of new chemical functionalities and applications.
Used in Chemical Research:
7-IODO-1-TETRALONE is also employed as a research tool in chemical investigations, where its unique properties can be explored to understand reaction mechanisms, develop new synthetic methodologies, and study the effects of structural modifications on chemical and biological activities. This application underscores its importance in advancing the fundamental knowledge of organic chemistry and its practical applications.

Upstream product

• 27913-58-2 4-(4-iodophenyl)butanoic acid 
• 1821-12-1 4-Phenylbutyric acid 

Relevant academic research and scientific papers

Design and synthesis of conformationally constrained analogues of cis-cinnamic acid and evaluation of their plant growth inhibitory activity

1-O-cis-Cinnamoyl-β-d-glucopyranose is known to be one of the most potent allelochemical candidates and was isolated from Spiraea thunbergii Sieb by Hiradate et al. (2004), who suggested that it derived its strong inhibitory activity from cis-cinnamic acid, which is crucial for phytotoxicity. In this study, key structural features and substituent effects of cis-cinnamic acid (cis-CA) on lettuce root growth inhibition was investigated. These structure-activity relationship studies indicated the importance of the spatial relationship of the aromatic ring and carboxylic acid moieties. In this context, conformationally constrained cis-CA analogues, in which the aromatic ring and cis-olefin were connected by a carbon bridge, were designed, synthesized, and evaluated as plant growth inhibitors. The results of the present study demonstrated that the inhibitory activities of the five-membered and six-membered bridged compounds were enhanced, up to 0.27 μM, and were ten times higher than cis-CA, while the potency of the other compounds was reduced.

Synthesis of 1-tetralones by intramolecular Friedel-Crafts reaction of 4-arylbutyric acids using Lewis acid catalysts

Intramolecular Friedel-Crafts reaction of 4-arylbutyric acids efficiently proceeded in the presence of catalytic amounts of Lewis acids such as Bi(NTf2)3 and M(OTf)3 (M=Bi, Ga, In and rare-earth metals) to form 1-tetralones. Chroman-4-one and thiochroman-4-one were also obtained in good yields from 3-phenoxypropionic acid and 3-phenylthiopropionic acid, respectively.

Benzo-fused lactams that promote the release of growth hormone

There are disclosed certain novel compounds identified as benzo-fused lactams which promote the release of growth hormone in humans and animals. This property can be utilized to promote the growth of food animals to render the production of edible meat products more efficient, and in humans, to increase the stature of those afflicted with a lack of a normal secretion of natural growth hormone. Growth promoting compositions containing such benzo-fused lactams as the active ingredient thereof are also disclosed.