1454885-39-2Relevant academic research and scientific papers
Discovery of novel (1S)-(-)-verbenone derivatives with anti-oxidant and anti-ischemic effects
Ju, Chung,Song, Sumi,Hwang, Sunyoung,Kim, Chorong,Kim, Minkyoung,Gu, Jail,Oh, Yu-Kyoung,Lee, Kyeong,Kwon, Jinsun,Lee, Kiho,Kim, Won-Ki,Choi, Yongseok
supporting information, p. 5421 - 5425 (2013/09/23)
A series of novel (1S)-(-)-verbenone derivatives was synthesized bearing a 4-styryl scaffold. The synthesized compounds were tested for their anti-oxidant, anti-excitotoxic, and anti-ischemic activities. These derivatives significantly reduced oxygen-glucose deprivation-induced neuronal injury and N-methyl-d-aspartic acid-evoked excitotoxicity in cortical neurons. Furthermore, compound 3f was identified as a potent anti-ischemic agent in an in vitro ischemic model, potentially due to the inhibition of N-methyl-d-aspartic acid-evoked excitotoxicity and oxidative/nitrosative stress.
