1454893-74-3Relevant academic research and scientific papers
Dichapetalins from dichapetalum species and their cytotoxic properties
Long, Christophe,Aussagues, Yannick,Molinier, Nicolas,Marcourt, Laurence,Vendier, Laure,Samson, Arnaud,Poughon, Valerie,Mutiso, Patrick B. Chalo,Ausseil, Frederic,Sautel, Francois,Arimondo, Paola B.,Massiot, Georges
, p. 184 - 191 (2013)
Six dichapetalins named dichapetalins N-S were isolated from Dichapetalum mombuttense, Dichapetalum zenkeri and Dichapetalum leucosia. They were accompanied in the same plants by the known dichapetalins A, B, C, I, L and M. The structures of the compounds were elucidated by 1D and 2D NMR experiments and mass spectrometry. They all possessed the dammarane skeleton substituted at position C-3 by a C6-C2 unit forming a 2-phenylpyran moiety. All contained a lactone ring in the side chain except dichapetalins O, Qand R, in which this ring was replaced by a lactol. Dichapetalin Qand R were also the first dichapetalins bearing a tertiary methyl and a double bond instead of the cyclopropane of the dammaranes. All these compounds were assayed against cancer cell lines HCT116 and WM 266-4 and displayed cytotoxic and anti-proliferative activities in the 10-6 to 10-8 M range.
