1454906-93-4Relevant academic research and scientific papers
Design, synthesis and biological evaluation of peptide derivatives of l-dopa as anti-parkinsonian agents
Zhou, Tao,Hider, Robert C.,Jenner, Peter,Campbell, Bruce,Hobbs, Christopher J.,Rose, Sarah,Jairaj, Mark,Tayarani-Binazir, Kayhan A.,Syme, Alexander
, p. 5279 - 5282 (2013/09/23)
A series of dipeptide derivatives of l-dopa were synthesized and investigated for their pharmacological activity using the unilaterally 6-hydroxydopamine (6-OHDA)-lesioned rat as an experimental model of Parkinson's disease. Among them, (S)-isopropyl 2-(2-amino-2-methylpropanamido)-3-(3,4- dihydroxyphenyl)propanoate (4g) was found to be the most active compound, with 106% AUC activity and 149% peak activity of l-dopa after oral administration.
