1454933-62-0

Upstream product

• 91-21-4 1,2,3,4-tetrahydroisoquinoline 
• 179897-89-3 5-Bromo-2-fluoro-benzonitrile 

Downstream Products

• 1454933-65-3 C₁₆H₁₄BrNO₂ 
• 1454933-31-3 5-bromo-2-(3,4-dihydroisoquinolin-2(1H)-yl)-N-(o-tolyl)benzamide 

Relevant academic research and scientific papers

Asymmetric cross-dehydrogenative coupling enabled by the design and application of chiral triazole-containing phosphoric acids

This report describes the development of an enantioselective C-N bond-forming reaction to produce 1,2,3,4-tetrahydroisoquinoline-derived cyclic aminals catalyzed by chiral phosphate anions. Central to the success of this goal was the design of a library of 3,3′-triazolyl BINOL-derived phosphoric acids capable of forming attractive hydrogen-bonding interactions with the peptide-like substrate. We envision this work will offer an alternative to the conventional strategy of increasing catalyst steric bulk to improve enantioselectivity with BINOL-derived phosphoric acids.

Perfluorobutyl Iodide Mediated [1,2] and [2,3] Stevens Rearrangement for the Synthesis of Indolin-3-Ones

The tertiary amine and ketone components of 1-carbonyl-substituted anilines undergo [1,2] and [2,3] Stevens rearrangement reactions, triggered by a C4F9 radical, formed from electron donor–acceptor complexes. This approach enables the formation of a quaternary ammonium salt and thus a Stevens rearrangement to afford indolin-3-ones under mild conditions. (Figure presented.).