145498-71-1

Upstream product

• 40615-39-2 5'-O-(4-4'-dimethoxytrityl)thymidine 
• 220063-81-0 1-[(2R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-([1,3,2]dithiaphospholan-2-yloxy)-tetrahydro-furan-2-yl]-5-methyl-1H-pyrimidine-2,4-dione 

Downstream Products

• 118149-25-0 O-5'-O-(Di-p-methoxytrityl)thymidin-3'-yl, O-3'-O-(acetyl)thymidin-5'-yl-phosphorodithioate 

Relevant academic research and scientific papers

New efficient synthesis of phosphonofluorodithioates ROP(S)(S-)F and their structural analogues

The title compounds 3 are formed in very high yield from a one-pot sequential reaction of 1,3,2-dithiaphospholane P(III) derivatives 1, which are transformed into the corresponding P(IV) compounds 2 by addition of elemental sulfur and finally into fluorid

Synthesis of P-fluorodithioacids of phosphorus and their synthetic application

Oligonucleotides containing 3′-S-P(S) and 5′-S-P(S) fragments in the deoxy-series are available only by tedious multistep procedures. We have developed a novel and efficient methodology based on ring opening of anhydronucleosides by phosphorus dithioacids