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5-(1H-pyrrol-1-yl)pentanoic acid, also known as Kynurenic acid (KYNA), is an endogenous product of the kynurenine pathway of tryptophan metabolism and a broad-spectrum antagonist of excitatory amino acid receptors. It is produced in the brain and acts as a neuroprotective agent by blocking the NMDA receptor and inhibiting the release of glutamate at synaptic terminals.

145511-35-9

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145511-35-9 Usage

Uses

Used in Pharmaceutical Industry:
5-(1H-pyrrol-1-yl)pentanoic acid is used as a neuroprotective agent for its ability to block the NMDA receptor and inhibit the release of glutamate at synaptic terminals, which can help in the management of various neurological disorders.
Used in Neurological Disorder Treatment:
5-(1H-pyrrol-1-yl)pentanoic acid is used as a potential therapeutic target for the management of cognitive dysfunction, chronic pain, and neuroinflammation due to its neuroprotective properties and its role in modulating various neurological pathways.
Used in Research:
5-(1H-pyrrol-1-yl)pentanoic acid is used as a research tool for studying the role of excitatory amino acid receptors and their involvement in neurological disorders, as well as for investigating the mechanisms of neuroprotection and neuroinflammation.

Check Digit Verification of cas no

The CAS Registry Mumber 145511-35-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,4,5,5,1 and 1 respectively; the second part has 2 digits, 3 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 145511-35:
(8*1)+(7*4)+(6*5)+(5*5)+(4*1)+(3*1)+(2*3)+(1*5)=109
109 % 10 = 9
So 145511-35-9 is a valid CAS Registry Number.

145511-35-9SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name 5-pyrrol-1-ylpentanoic acid

1.2 Other means of identification

Product number -
Other names -

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
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More Details:145511-35-9 SDS

145511-35-9Relevant academic research and scientific papers

DIHYDROINDOLIZINE DERIVATE AS METABOTROPIC GLUTAMATE RECEPTOR MODULATORS

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Page/Page column 62, (2013/02/28)

The invention relates to heterocyclic derivatives of formula I, wherein the substituents R1-R5 and R11 are as defined in the claims, as well as their pharmaceutically acceptable salts. The invention further relates to a process for the preparation of such compounds. The compounds of the invention are mGluR5 modulators and are therefore useful for the control and prevention of acute and/or chronic neurological disorders.

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