145511-50-8

Basic information

• Product Name: (3aR)-8-methyl-2,3,3a,4,5,6-hexahydro-1H-pyrazino[3,2,1-jk]carbazole hydrochloride
• CAS NO: 145511-50-8
• Molecular Formula: C₁₅H₁₉ClN₂
• Molecular Weight: 262.7778
• Mol File: 145511-50-8.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 422.6°C at 760 mmHg
• Flash Point: 209.4°C
• Vapor Pressure: 2.39E-07mmHg at 25°C
• CAS DataBase Reference: (3aR)-8-methyl-2,3,3a,4,5,6-hexahydro-1H-pyrazino[3,2,1-jk]carbazole hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: (3aR)-8-methyl-2,3,3a,4,5,6-hexahydro-1H-pyrazino[3,2,1-jk]carbazole hydrochloride(145511-50-8)
• EPA Substance Registry System: (3aR)-8-methyl-2,3,3a,4,5,6-hexahydro-1H-pyrazino[3,2,1-jk]carbazole hydrochloride(145511-50-8)

Safety Data

• Hazardous Substances Data: 145511-50-8(Hazardous Substances Data)

Usage

General Description

The chemical (3aR)-8-methyl-2,3,3a,4,5,6-hexahydro-1H-pyrazino[3,2,1-jk]carbazole hydrochloride, also known as ketanserin, is a pharmaceutical compound commonly used as a medication for the treatment of hypertension and migraines. It belongs to the class of drugs known as serotonin receptor antagonists, specifically functioning as a selective 5-HT2A receptor antagonist. This makes it useful in reducing the vasoconstrictive effects of serotonin and in turn, lowering blood pressure. Additionally, ketanserin also exhibits potential anti-inflammatory and anti-tumor properties, and has been the subject of research for its potential therapeutic applications in various medical conditions.

Upstream product

• 110951-51-4 6-Methyl-1-(2-chloroethylimino)-1,2,3,4-tetrahydrocarbazole hydrochloride 
• 3449-48-7 6-methyl-2,3,4,9-tetrahydro-1H-carbazol-1-one 
• 73166-21-9 8-Methyl-2,4,5,6-tetrahydro-1H-pyrazino[3,2,1-jk]carbazole; hydrochloride 
• 145100-72-7 8-Methyl-3-(1-phenyl-ethyl)-2,3,3a,4,5,6-hexahydro-1H-pyrazino[3,2,1-jk]carbazole 
• 110951-52-5 (2-Chloro-ethyl)-(6-methyl-2,3,4,9-tetrahydro-1H-carbazol-1-yl)-amine 
• 15932-34-0 5,6-dihydro-8-methyl-4H-pyrazino<3,2,1-j,k>carbazole hydrochloride 
• 110951-48-9 6-Methyl-1-(2-hydroxyethylimino)-1,2,3,4-tetrahydrocarbazole 

Downstream Products

• 73166-21-9 8-Methyl-2,4,5,6-tetrahydro-1H-pyrazino[3,2,1-jk]carbazole; hydrochloride 

Relevant articles and documents

NEW APPROACH TO THE SYNTHESIS OF PYRAZIDOL

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First Preparative Enantiomer Resolution of Pirlindole, a Potent Antidepressant Drug

Pirlindole is an antidepressant drug. It acts principally as reversible inhibitor of monoamine oxidase-A (RIMA) and appears relatively potent in comparison with reference drugs. Pirlindole possesses stereogenic center but is generally used as racemate. In this work, the first preparative resolution of its enantiomeric couple is described. Whereas selective crystallization of salts of chiral acid failed, two asymmetric synthetic pathways were also examined; however, without success. Finally separation and isolation of enantiomers of pirlindole was completed by using the derivatization method coupled with preparative HPLC. Optical purity of each isomer was determined by chiral HPLC. The specific rotation of each antipode was also determined.