145545-23-9

Usage

Uses

Des-(3-Indolyl) 3-(Phenylamino) Tryptophan is the impurity of Tryptophan (T947210), which is an essential amino acid.

InChI:InChI=1/C9H12N2O2/c10-8(9(12)13)6-11-7-4-2-1-3-5-7/h1-5,8,11H,6,10H2,(H,12,13)

Upstream product

• 4916-27-2 (+/-)-1-phenylaziridine-2-carbonitrile 
• 933782-78-6 S-(-)-1-phenylaziridine-2-carboxamide 
• 933453-68-0 R-(-)-2-azido-3-[benzyl(phenyl)amino]propanamide 
• 302-84-1 serin 
• 62-53-3 aniline 

Relevant academic research and scientific papers

Nitrile biotransformations for the efficient synthesis of highly enantiopure 1-arylaziridine-2-carboxylic acid derivatives and their stereoselective ring-opening reactions

Catalyzed by the Rhodococcus erythropolis AJ270 whole cell catalyst under very mild conditions, biotransformations of racemic 1-arylaziridine-2- carbonitriles proceeded efficiently and enantioselectively to produce highly enantiopure S-1-arylaziridine-2-c

Substituted benzimidazoles

Compounds of formula I are suitable for the production of pharmaceuticals for the prophylaxis and therapy of disorders in whose course an increased activity of NFκB is involved.

Formation of a 3-(Phenylamino)alanine Contaminant in EMS-associated L-Tryptophan

Chemical studies were conducted to determine the origin of the 3-(phenylamino)alanine (PAA) contaminant in EMS-associated L-tryptophan samples.Anthranilic acid, a biosynthetic precursor of the L-tryptophan, was heated at 80 deg C for 6 h under acidic conditions to produce 140 μg of aniline/g of anthranilic acid.The presence of aniline was verified by HPLC-UV and GC-MS.PAA (160 μg of PAA/g of aniline) was produced by heating aniline and serine at 80 deg C for 6 h under basic conditions.PAA was confirmed by HPLC-UV and LC-MS.These results suggest that PAA could be formed under the fermentation and purification conditions used to produce L-tryptophan on an industrial scale.