1455471-63-2

Upstream product

• 96-98-0 4-methyl-3-nitrobenzoic acid 
• 1455471-62-1 sodium (4-(methoxycarbonyl)-2-nitrophenyl)methanesulfonate 
• 88089-94-5 methyl 4-bromomethyl-3-nitrobenzoate 
• 7356-11-8 4-methyl-3-nitro-benzoic acid methyl ester 

Downstream Products

• 1455471-65-4 methyl 1-benzyl-1,3-dihydrobenzo[c]isothiazol-6-carboxylate 2,2-dioxide 
• 1455471-66-5 1-benzyl-1,3-dihydrobenzo[c]isothiazol-6-carboxylic acid 2,2-dioxide 
• 1455471-68-7 1-(1-benzyl-2,2-dioxido-1,3-dihydrobenzo[c]isothiazol-6-yl)-2-diazoethanone 
• 1455471-69-8 methyl 2-(1-benzyl-2,2-dioxido-1,3-dihydrobenzo[c]isothiazol-6-yl)acetate 
• 1455473-50-3 C₁₅H₁₂ClNO₃S 

Relevant academic research and scientific papers

HETEROCYCLIC SMALL MOLECULE MODULATORS OF HUMAN STING

The present invention relates to compounds of formula (I). The compounds may be used to modulate the Stimulator of Interferon Genes (STING) protein and thereby treat diseases such as cancer and microbial infections. (I)

SUBSTITUTED HETEROCYCLIC ACETAMIDES AS KAPPA OPIOID RECEPTOR (KOR) AGONISTS

The present invention relates to a series of substituted compounds having the general formula (I), including their ste reoisomers and/or their pharmaceutically acceptable salts, wherein R1, R2, R3. R4, R5, and R6 are as defined herein. This invention also relates to methods of making these compounds including intermediates. The compounds of this invention are effective at the kappa (κ) opioid receptor (KOR) site. Therefore, the compounds of this invention are useful as pharmaceutical agents, especially in the treatment and/or prevention of a variety of central nervous system disorders (CNS), including but not limited to acute and chronic pain, and associated disorders, particularly functioning peripherally at the CNS.