14555-22-7

Upstream product

• 65200-70-6 2-(2-methoxyphenyl)-1-(4-methoxyphenyl)ethan-1-one 

Downstream Products

• 14336-13-1 2-(2-methoxy-phenyl)-2-(4-methoxy-phenyl)-thioacetamide 
• 14462-69-2 2-(2,4'-diacetoxy-benzhydryl)-4-methyl-thiazole 
• 14406-59-8 2-(2,4'-dimethoxy-benzhydryl)-4-methyl-thiazole 
• 14406-60-1 4,2'-(4-methyl-thiazol-2-ylmethanediyl)-bis-phenol 

Relevant academic research and scientific papers

BF3·OEt2-mediated [1,2]-aryl shift: Synthesis of functionalized α-arylnitriles via the bromination/cyanation/deformylation of substituted deoxybenzoin

A new sequential, tandem synthesis of functionalized α-arylnitriles via the bromination/cyanation/deformylation of substituted deoxybenzoin has developed. CuBr2-promoted bromination of substituted deoxybenzoins gives 2-bromo-2-arylacetophenne 3. The cyanation of 3 with sodium cyanide (NaCN) generates epoxynitrile. Then, a treatment of epoxynitrile with BF3·OEt2 results in the formation of functionalized α-arylnitriles 4 via a 1,2-aryl shift.