145576-79-0Relevant academic research and scientific papers
New methodology for the synthesis of unsaturated 8-, 9- and 10-membered lactams
Evans, P. Andrew,Holmes, Andrew B.,McGeary, Ross P.,Nadin, Alan,Russell, Keith,O'Hanlon, Peter J.,Pearson, Neil D.
, p. 123 - 138 (2007/10/03)
Unsaturated 8-, 9- and 10-membered medium ring lactams 1 (n = 1, 2, 3) have been prepared in good yield by the Claisen rearrangement of the vinyl-substituted precursors 3 in the presence of 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU).
Synthesis of Monocyclic Medium Ring Lactams
Evans, P. Andrew,Holmes, Andrew B.,Russell, Keith
, p. 6857 - 6858 (2007/10/02)
The Claisen rearrangement of the vinyl substituted ketene aminals 4a-c which were generated in situ by selenoxide elimination of the aminal precursors 3a-c in the presence of 1,8-diazabicycloundec-7-ene gave the monocyclic unsaturated medium ring l
