145593-69-7Relevant academic research and scientific papers
Transition Metal-Catalyzed Radical Cyclizations: A Low-Temperature Process for the Cyclization of N-Protected N-Allyltrichloroacetamides to Trichlorinated γ-Lactams and Application to the Stereoselective Preparation of β,γ-Disubstituted γ-Lactams
Nagashima, Hideo,Ozaki, Nobuyasu,Ishii, Masayuki,Seki, Koji,Washiyama, Masayoshi,Itoh, Kenji
, p. 464 - 470 (2007/10/02)
Cyclisations of N-substituted N-allyltrichloroacetamides, where the substituent is an alkyl, Cbz, Boc, Ts, or Ms group, are catalyzed by a 1:1 mixture of CuCl and bipyridine to give the corresponding β,γ-trichlorinated γ-lactams in high yields.The reactions proceed at temperatures from -78 deg C to room temperature.Cyclizations of N-allyltrichloroacetamides of acyclic secondary allylic amines are achieved with good selectivity; the cis/trans ratios of the γ-lactams formed were dependent on the substituents on the nitrogen atom.The stereochemical outcome is compared with that of free-radical cyclization.
Highly Stereoselective Radical Cyclization: Copper- or Ruthenium-Catalyzed Preparation of cis- and trans-β,γ-Dialkyl γ-Lactams from Acyclic N-Allyltrichloroacetamide Derivatives
Nagashima, Hideo,Ozaki, Nobuyasu,Seki, Koji,Ishii, Masayuki,Itoh, Kenji
, p. 4497 - 4499 (2007/10/02)
Efficient 1,2-asymmetric induction was achieved in the copper-catalyzed cyclization of N-allyltrichloroacetamides derived from 3-amino-1-butene or 3-amino-1-heptene, in which the stereochemical course was dependent on nitrogen protecting groups.
