1456-20-8Relevant academic research and scientific papers
2,5-Disubstituted-1,3,4-oxadiazoles: Thymidine phosphorylase inhibitors
Khan, Khalid Mohammed,Rani, Mubeen,Ambreen, Nida,Ali, Muhammad,Hussain, Sajjad,Perveen, Shahnaz,Choudhary, Muhammad Iqbal
, p. 6022 - 6028 (2013/11/06)
A series of 2,5-disubstituted-1,3,4-oxadiazoles (1-16) were synthesized via microwave irradiation and screened against thymidine phosphorylase enzyme. Four members of the series have demonstrated thymidine phosphorylase inhibitory activities with IC50 values between 37 and 320 μM. Pyridinyl-containing 1,3,4-oxadiazoles exhibited an enhanced inhibitory potential, while phenyl analogs did not show substantial inhibitory potential. Compound 9, a dipyridinyl residue having an IC50 value of 37 ± 0.76 μM was found to be the most potent in the series superior to standard inhibitor 7-deazaxanthine (IC50 = 39.28 ± 0.76 μM). Graphical abstract: [InlineMediaObject not available: see fulltext.]
Reaction of 5-Substituted tetrazoles with trifluoroacetic anhydride
Vereshchagin,Verkhozina,Pokatilov,Strunevich,Proidakov,Kizhnyaev
, p. 1710 - 1714 (2008/09/18)
5-Substituted tetrazoles readily react with trifluoroacetic anhydride at 20-25°C to give the corresponding 2-substituted 5-trifluoromethyl-1,3,4- oxadiazoles, in contrast to published data according to which the title compounds are converted into 1,3,4-oxadiazole derivatives on heating with carboxylic acid anhydrides or chlorides at 100-120°C. The reaction is governed not only by the rate of acylation of the tetrazole ring and temperature conditions but also by the stability of intermediate N-acyltetrazoles.
TETRAZOLES IN THE SYNTHESES OF 1,3,4-OXADIAZOLES
Koldobskii, G. I.,Ivanova, S. E.
, p. 1512 - 1517 (2007/10/03)
Various variants of cleavage of tetrazoles to form 1,3,4-oxadiazoles are examined.The mechanisms and synthetic potentialities of these reactions are discussed.
