1456-20-8

Basic information

• Product Name: 1,3,4-Oxadiazole, 2-phenyl-5-(trichloromethyl)-
• CAS NO: 1456-20-8
• Molecular Formula: C9H5Cl3N2O
• Molecular Weight: 263.51
• Mol File: 1456-20-8.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 1,3,4-Oxadiazole, 2-phenyl-5-(trichloromethyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1,3,4-Oxadiazole, 2-phenyl-5-(trichloromethyl)-(1456-20-8)
• EPA Substance Registry System: 1,3,4-Oxadiazole, 2-phenyl-5-(trichloromethyl)-(1456-20-8)

Safety Data

• Hazardous Substances Data: 1456-20-8(Hazardous Substances Data)

Usage

Type of compound

Heterocyclic compound

Structure

Contains an oxadiazole ring and a phenyl group attached to the nitrogen atom

Additional functional group

Trichloromethyl group

Usage

Pharmaceutical and agricultural industries as a building block for the synthesis of various biologically active compounds and pesticides

Biological activity

Exhibits potential biological activity and is under research for various applications

Safety precautions

Handle with caution due to possible toxic and hazardous properties

Upstream product

• 613-94-5 benzoic acid hydrazide 
• 76-03-9 trichloroacetic acid 
• 883804-35-1 5-phenyltetrazole 
• 76-02-8 trifluoroacetyl chloride 
• 93-97-0 benzoic acid anhydride 
• 85916-02-5 5-Trichlormethyltetrazol 

Relevant articles and documents

2,5-Disubstituted-1,3,4-oxadiazoles: Thymidine phosphorylase inhibitors

A series of 2,5-disubstituted-1,3,4-oxadiazoles (1-16) were synthesized via microwave irradiation and screened against thymidine phosphorylase enzyme. Four members of the series have demonstrated thymidine phosphorylase inhibitory activities with IC50 values between 37 and 320 μM. Pyridinyl-containing 1,3,4-oxadiazoles exhibited an enhanced inhibitory potential, while phenyl analogs did not show substantial inhibitory potential. Compound 9, a dipyridinyl residue having an IC50 value of 37 ± 0.76 μM was found to be the most potent in the series superior to standard inhibitor 7-deazaxanthine (IC50 = 39.28 ± 0.76 μM). Graphical abstract: [InlineMediaObject not available: see fulltext.]

TETRAZOLES IN THE SYNTHESES OF 1,3,4-OXADIAZOLES

Various variants of cleavage of tetrazoles to form 1,3,4-oxadiazoles are examined.The mechanisms and synthetic potentialities of these reactions are discussed.