145600-72-2

Upstream product

• 1396038-77-9 N,N-3-(dimethylamino)-4-(methoxymethyl)benzyl alcohol 
• 1396038-68-8 N,N-3-(dimethylamino)-4-(methoxymethyl)benzoic acid methyl ester 

Downstream Products

• 145600-44-8 4-[4-(4-chlorobenzhydryl)piperazino]methyl-2-dimethylaminophenol 
• 1396037-00-5 2-methoxy-(E,E)-4,6-bis(4'-methoxymethoxy-3'-N,N-dimethylaminostyryl)pyrimidine 
• 1236355-42-2 2-methoxy-(E,E)-4,6-bis-(4'-hydroxy-3'-N,N-dimethylaminostyryl)pyrimidine 
• 1396037-29-8 2-methylthio-(E,E)-4,6-bis(4'-methoxymethoxy-3'-N,N-dimethylaminostyryl)pyrimidine 
• 1236355-48-8 2-methylthio-(E,E)-4,6-bis-(4'-hydroxy-3'-N,N-dimethylaminostyryl)pyrimidine 
• 1236355-53-5 (E,E)-3,5-bis[4'-hydroxy-3'-(N,N-dimethylamino)styryl]phenol 
• 1236355-54-6 (E,E)-3,5-bis[3'-hydroxy-4'-(N,N-dimethylamino)styryl]phenol 
• 1396037-90-3 (E,E)-3,5-bis(3'-methoxymethoxy-4'-N,N-dimethylaminostyryl)phenol 
• 1396037-57-2 (E,E)-3,5-bis(4'-methoxymethoxy-3'-N,N-dimethylaminostyryl)benzene 
• 1236355-32-0 (E,E)-4,6-bis(4'-hydroxy-3'-(N_.N-dimethylamino)styryl)pyrimidine 
• 1236355-56-8 (E,E)-4,6-bis(4'-methoxymethoxy-3'-N,N-dimethylaminostyryl)pyrimidine 

Relevant academic research and scientific papers

Small molecules that protect against β-amyloid-induced cytotoxicity by inhibiting aggregation of β-amyloid

Aggregated β-amyloid (Aβ) plays crucial roles in Alzheimer's disease (AD) pathogenesis, therefore blockade of Aβ aggregation is considered as a potential therapeutic target. We designed and synthesized small molecules to reduce Aβ-induced cytotoxicity by inhibiting Aβ aggregation. The small molecules were screened via ThT, MTT, and cell-based cytotoxicity assay (Aβ burden assay). Selected compounds 1c, 1d, 1e, and 1f were then investigated by evaluating their effects on cognitive impairment of acute AD mice model. Learning and memory dysfunction by injection of Aβ(1-42) was recovered by administration of these molecules. Especially, 1d showed the best recovery activity in Y-maze task, object recognition task, and passive avoidance task with dose dependent manner. These results suggest that 1d has high potential as a therapeutic agent for AD.

Substituted or unsubstituted benzhydryl heteroalkyl-substituted aminophenol compounds and pharmaceutical compositions thereof

Aminophenol derivatives of the following formula (I) STR1 wherein X is hydrogen atom, lower alkyl or a protecting group for phenolic hydroxy, Y is hydrogen atom or lower alkyl, Z is hydrogen atom, lower alkyl, halogen atom or trifluoromethyl, A is hydrogen atom or lower alkyl, t is an integer of 1 to 5, l and m are respectively an integer of 2 to 4, E and W are nitrogen atoms, F is a direct bond or oxygen atom, P and Q are each hydrogen atom, halogen atom, lower alkyl or lower alkoxy, and R8 is hydrogen atom, hydroxy or a hydroxy-protecting group, and their pharmcologically acceptable salts. Since the aminophenol derivatives (I) of the present invention have excellent antioxidative action and antiinflammatory and antiallergic action in mammalian animals including human, they are extremely useful as pharmaceuticals such as an antiinflammatory or an antiallergic.