145602-77-3Relevant academic research and scientific papers
Copper-Catalyzed Oxy-aminomethylation of Diazo Compounds with N, O-Acetals
Yu, Jianliang,Chen, Long,Sun, Jiangtao
supporting information, p. 1664 - 1667 (2019/03/11)
A novel oxy-aminomethylation reaction of diazo compounds has been developed, providing the α-hydroxy-β2-amino acid derivatives with quaternary carbon centers in moderate to excellent yields. Importantly, the readily available N,O-acetals have been employed as efficient bifunctionalization reagents to react with copper carbene intermediates, leading to the concurrent incorporation of an alkoxy and an iminium group into one molecule. Moreover, a water-involved three-component reaction occurs to deliver the free-hydroxy amino acid derivatives.
Selective synthesis of diaryl and monoaryl substituted porphyrins
Hombrecher,Horter,Arp
, p. 9451 - 9460 (2007/10/02)
A selective synthetic method to monoaryl and diaryl substituted porphyrins is described. Depending on the nature of the β-substituent the synthesized porphyrins show different degrees of ruffling of the chromophor.
The synthesis of α-amino-substituted diphenylphosphine oxides
Broekhof, N. L. J. M.,Elburg, P. van,Gen, A. van der
, p. 312 - 316 (2007/10/02)
Four methods with differing but overlapping specificity are described for the synthesis of α-unsubstituted as well as α-substituted (aminomethyl)diphenylphosphine oxides.The first method is based on the Arbusov reaction, the second on a Mannich-type condensation of diphenylphosphine oxide with aldehydes and secondary amines, the third on the addition of Ph2P(O)H to enamines and the fourth on the reaction of anions derived from α-unsubstituted (aminomethyl)diphenylphosphine oxides with various electrophiles.
