1456070-75-9

Upstream product

• 133342-12-8 ethyl [6-(4-methoxyphenyl)-3(2H)-pyridazinon-2-yl]acetate 
• 2166-33-8 6-(4-methoxyphenyl)-2H-pyridazin-3-one 
• 100-06-1 1-(4-methoxyphenyl)ethanone 

Downstream Products

• 1456070-65-7 N'-(phenylmethylidene)-2-[6-(4-methoxyphenyl)-3-oxo-2H-pyridazin-2-yl]acetohydrazide 
• 1456070-66-8 N'-[(4-methylphenyl)methylidene]-2-[6-(4-methoxyphenyl)-3-oxo-2H-pyridazin-2-yl]acetohydrazide 
• 1456070-67-9 N'-[(4-chlorophenyl)methylidene]-2-[6-(4-methoxyphenyl)-3-oxo-2H-pyridazin-2-yl]acetohydrazide 
• 1456070-68-0 N'-[(4-methoxyphenyl)methylidene]-2-[6-(4-methoxyphenyl)-3-oxo-2H-pyridazin-2-yl]acetohydrazide 
• 1456070-69-1 N'-[(4-fluorophenyl)methylidene]-2-[6-(4-methoxyphenyl)-3-oxo-2H-pyridazin-2-yl]acetohydrazide 

Relevant academic research and scientific papers

Synthesis of some new 3(2H)-pyridazinone derivatives and evaluation of their analgesic-anti-inflammatory and antimicrobial activities

In this study, 15 new 3(2H)-pyridazinone derivatives carrying N'-(4-substitutedphenylmethylidene)acetohydrazide moiety on lactam nitrogen were synthesized and their chemical structures were confirmed by 1H-NMR, mass, and elemental analysis. Analgesic and anti-inflammatory activities of the synthesized compounds were evaluated in mice. Among the synthesized compounds, compound 11e exhibited the best analgesic and anti-inflammatory activities, without causing any gastric effect in stomachs of tested animals. Additionally, the synthesized compounds were screened for their antibacterial and antifungal activities against some pathogenic strains.