145625-29-2Relevant academic research and scientific papers
The design of dipeptide helical mimetics, Part I: The synthesis of 1,6-disubstituted indanes
Horwell, David C.,Howson, William,Nolan, William P.,Ratcliffe, Giles S.,Rees, David C.,Willems, Henriette M. G.
, p. 203 - 216 (1995)
The design and synthesis of conformationally restrained, non-peptide templates (1,6-disubstituted indanes) which allow the incorporation of two adjacent amino acid side-chains in an orientation similar to that found in alpha-helices is reported.
The synthesis of 1,6-disubstituted indanes which mimic the orientation of amino acid side-chains in a protein alpha-helix motif.
Nolan,Ratcliffe,Rees
, p. 6879 - 6882 (2007/10/02)
We utilize a 1,6-disubstituted indane as a template onto which two amino acid side-chains are appended in an orientation which mimics that found in a protein alpha-helix motif.
