145626-87-5 Usage
Chemical Properties
White Crystalline Solid
Uses
Different sources of media describe the Uses of 145626-87-5 differently. You can refer to the following data:
1. Bis(2-mercaptoethyl) sulfone is a useful reagent for the reduction of disulfides in aquous solutions. It is a superior substitute for DTT.
2. Reagent for reduction of disulfide bonds in aqueous solutions.
Purification Methods
BMS recrystallises from hexane as white fluffy crystals. Large amounts are best recrystallised from de-oxygenated H2O (charcoal). It is a good alternative reducing agent to dithiothreitol. Its IR (film) has 2995, 2657, 1306, 1248, 1124 and 729 cm-1 . The synthetic intermediate thioacetate has m 82-83o (white crystals from CCl4). The disulfide is purified by flash chromatography on SiO2 and elution with 50% EtOAc/hexane and recrystallised from hexane, and has m 137-139o. [Lamoureux & Whitesides J Org Chem 58 633 1993, Beilstein 1 IV 2455.]
Check Digit Verification of cas no
The CAS Registry Mumber 145626-87-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,4,5,6,2 and 6 respectively; the second part has 2 digits, 8 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 145626-87:
(8*1)+(7*4)+(6*5)+(5*6)+(4*2)+(3*6)+(2*8)+(1*7)=145
145 % 10 = 5
So 145626-87-5 is a valid CAS Registry Number.
InChI:InChI=1/C4H10O2S3/c5-9(6,3-1-7)4-2-8/h7-8H,1-4H2
145626-87-5Relevant articles and documents
Synthesis of Dithiols as Reducing Agents for Disulfides in Neutral Aqueous Solution and Comparison of Reduction Potentials
Lamoureux, Guy V.,Whitesides, George M.
, p. 633 - 641 (2007/10/02)
Several dithiols have been prepared that are useful for the reduction of disulfides in aqueous solution.The reduction potential of these thiols have been determined from the measurement of the equilibrium constant of thiol/disulfide interchange with oxidized dithiothreitol using a 1H NMR assay.The values of pKa of some of the dithiols were measured to estimate their rate of reduction of disulfides.Bis(2-mercaptoethyl) sulfone (2), N,N'-dimethyl-N,N'-bis(mercaptoacetyl)hydrazine (5), and meso-2,5-dimercapto-N,N,N',N'-tetramethyladipamide (6) are especially interesting as alternatives to dithiothreitol for the reduction of disulfides.
