14563-35-0Relevant academic research and scientific papers
Catalytic Redox Chain Ring Opening of Lactones with Quinones to Synthesize Quinone-Containing Carboxylic Acids
Xu, Xiao-Long,Li, Zhi
, p. 5078 - 5081 (2019/09/03)
Catalytic ring opening of five- to eight-membered lactones with quinones is achieved through a redox chain mechanism. With low loading of a simple metal triflate Lewis acid catalyst and a chain initiator, C-H bonds of many quinones were efficiently functionalized with carboxylic acid-containing side chains. This method also features 100% atom economy and wide substrate scope. A novel route to the anti-asthma drug Seratrodast was developed. Mechanism study suggests that the redox chain reaction likely undergoes a carbocation intermediate.
A Direct Route for the Regioselective Synthesis of Hydroxylated Aromatic Cycloalkanediones
Sartori, Giovanni,Bigi, Franca,Goffredi, Gino,Maggi, Raimondo,Portioli, Roberto,Casnati, Giuseppe
, p. 2061 - 2079 (2007/10/02)
A "one-pot" regioselective synthesis of hydroxylated aromatic cycloalkanediones 1 from phenols or their methyl ethers and aliphatic dicarboxylic acid chlorides is reported.
