145655-14-7

Basic information

• Product Name: 2,3,5-Pyridinetricarboxylic acid, 6-methyl-4-(2-nitrophenyl)-, 3,5-dimethyl ester
• CAS NO: 145655-14-7
• Molecular Formula: C17H14N2O8
• Molecular Weight: 374.307
• Mol File: 145655-14-7.mol

Chemical Properties

• CAS DataBase Reference: 2,3,5-Pyridinetricarboxylic acid, 6-methyl-4-(2-nitrophenyl)-, 3,5-dimethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 2,3,5-Pyridinetricarboxylic acid, 6-methyl-4-(2-nitrophenyl)-, 3,5-dimethyl ester(145655-14-7)
• EPA Substance Registry System: 2,3,5-Pyridinetricarboxylic acid, 6-methyl-4-(2-nitrophenyl)-, 3,5-dimethyl ester(145655-14-7)

Safety Data

• Hazardous Substances Data: 145655-14-7(Hazardous Substances Data)

Upstream product

• 21829-25-4 nifedipine 

Relevant articles and documents

Biotransformation of nifedipine in rat and dog

Following oral and/or intraduodenal administration, the biotransformation of 14C-labelled nifedipine (dimethyl 1,4-dihydro-2,6-dimethyl-4-(2-nitrophenyl)-pyridine-3,5-dicarboxylate, Bay a 1040, Adalat, CAS 21829-25-4) has been reinvestigated in rats and dogs (dose: 5 mg/kg body weight in both species) to complete the metabolic data. Thirteen metabolites were isolated from the perfusate and bile of the isolated perfused rat liver model. Their structures were elucidated by spectroscopic methods (FAB-MS, combined GG/MS, NMR). The analyzed samples were used for the chromatographic (HPLC) comparison with urine and bile from the in vivo studies. The metabolites identified in rat urine (oral dose) account for 47.4% of the dose administered. 82.8% (rat) and 62.8% (dog) of the dose, resp., could be attributed to known structures in urine and bile following intraduodenal administration. Based on the structures identified the following biotransformation steps occured: dehydrogenation of the 1,4-dihydropyridine system, hydroxylation of the methyl groups at 2- or 6-position followed by glucuronidation or by subsequent oxidation to the carboxylic acid, and oxidative ester cleavage.