145655-47-6

Basic information

• Product Name: (2E,4E)-5-(4-Chloro-phenyl)-2-methyl-penta-2,4-dienoic acid
• Synonyms: (2E,4E)-5-(4-Chloro-phenyl)-2-methyl-penta-2,4-dienoic acid
• CAS NO: 145655-47-6
• Molecular Weight: 222.671
• Mol File: 145655-47-6.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (2E,4E)-5-(4-Chloro-phenyl)-2-methyl-penta-2,4-dienoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: (2E,4E)-5-(4-Chloro-phenyl)-2-methyl-penta-2,4-dienoic acid(145655-47-6)
• EPA Substance Registry System: (2E,4E)-5-(4-Chloro-phenyl)-2-methyl-penta-2,4-dienoic acid(145655-47-6)

Safety Data

• Hazardous Substances Data: 145655-47-6(Hazardous Substances Data)

Upstream product

• 89812-66-8 (2E,4E)-5-(4-Chloro-phenyl)-2-methyl-penta-2,4-dienoic acid methyl ester 
• 7560-44-3 methyl 4-chlorocinnamate 
• 1075-77-0 4-chlorocinnamaldehyde 
• 24583-70-8 3-(4-chlorophenyl)-2-propene-1-ol 
• 104-88-1 4-chlorobenzaldehyde 
• 145655-37-4 1-(4-chlorophenyl)allyl acrylate 

Relevant articles and documents

Highly Regio- A nd Enantioselective Hydrogenation of Conjugated α-Substituted Dienoic Acids

Highly regio- A nd enantioselective hydrogenation of conjugated α-substituted dienoic acids was realized for the first time using Trifer-Rh complex, providing a straightforward method for the synthesis of chiral α-substituted ?,?′-unsaturated acids. DFT calculations revealed N+H-O hydrogen bonding interaction is formed to stabilize the transition state and the coordination of 4,5-double bond to Rh(III) center would facilitate the reductive elimination process. This hydrogenation provided a gram-scale synthesis of the precursor of sacubitril.