1456553-26-6

Basic information

• Product Name: GalNAc beta(1-3)GlcNAc-beta-pNP
• Synonyms: GalNAc beta(1-3)GlcNAc-beta-pNP;4-Nitrophenyl 2-Acetamido-2-deoxy-3-O-(2-acetamido-2-deoxy-beta-D-galactopyranosyl)-beta-D-glucopyranoside;GalNAcβ(1-3)GlcNAc-βN-[(2R,3S,4R,5R,6S)-2-[(2S,3S,4R,5S,6S)-5-acetamido-3-hydroxy-2-(hydroxymethyl)-6-(4-nitrophenoxy)oxan-4-yl]oxy-4,5-dihydroxy-6-(hydroxymethyl)oxan-3-yl]acetamide
• CAS NO: 1456553-26-6
• Molecular Formula: C22H31N3O13
• Molecular Weight: 545.49
• Mol File: 1456553-26-6.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 965.4±65.0 °C(Predicted)
• Appearance: /
• Density: 1.55±0.1 g/cm3(Predicted)
• Storage Temp.: <0°C
• PKA: 12.67±0.70(Predicted)
• CAS DataBase Reference: GalNAc beta(1-3)GlcNAc-beta-pNP(CAS DataBase Reference)
• NIST Chemistry Reference: GalNAc beta(1-3)GlcNAc-beta-pNP(1456553-26-6)
• EPA Substance Registry System: GalNAc beta(1-3)GlcNAc-beta-pNP(1456553-26-6)

Safety Data

• Hazardous Substances Data: 1456553-26-6(Hazardous Substances Data)

Usage

Uses

GalNAc beta(1-3)GlcNAc-beta-pNP is a biochemical for proteomics research.

Upstream product

• 83025-20-1 3,4,6-tri-O-acetyl-2-azido-2-deoxy-α-D-galactopyranosyltrichloroacetimidate 
• 1316823-27-4 p-nitrophenyl 3,4,6-tri-O-acetyl-2-azido-2-deoxy-α-D-galactopyranosyl-(1->3)-2-azido-2-deoxy-α-D-galactopyranoside 
• 100-02-7 4-nitro-phenol 
• 1147438-51-4 p-nitrophenyl 3,4,6-tri-O-acetyl-2-azido-2-deoxy-α-D-galactopyranoside 
• 1316823-24-1 p-nitrophenyl 3,4,6-tri-O-acetyl-2-deoxy-2-phthalimido-β-D-glucopyranosyl-(1->3)-2-azido-2-deoxy-α-D-galactopyranoside 
• 1316823-20-7 p-nitrophenyl 3,4,6-tri-O-acetyl-2-deoxy-2-phthalimido-β-D-glucopyranosyl-(1->3)-2-azido-2-deoxy-4,6-O-p-methoxybenzylidene-α-D-galactopyranoside 
• 10139-02-3 1-(4-nitrophenyl)-2-desoxy-2-acetylamino-α-D-glucopyranoside 
• 14200-67-0 N,N'-diacetylchitobiose 
• 1316822-99-7 p-nitrophenyl 2-azido-2-deoxy-4,6-O-p-methoxybenzylidene-α-D-galactopyranoside 
• 210418-04-5 C₁₂H₁₄N₄O₇ 

Relevant articles and documents

Synthesis of mucin O-glycan core structures as their p-nitro- and p-aminophenyl glycosides

For the investigation of glycosidases, and for the construction of glycan arrays the p-nitrophenyl- and p-aminophenyl glycosides of mucin O-glycan core structures 1-7 and the 2,6-ST-antigen have been chemically synthesized using d-galactose as a precursor for GalNAc residues. GlcNAc residues have partly been introduced using a 4,6-di-O-benzoyl-2,3-N,O-oxazolidinone-protected donor, which allowed deprotection of the formed di- and tri-saccharides in one step using sodium methoxide.

N-ACETYLGLUCOSAMINYL DISACCHARIDE AND TRISACCHARIDE FORMATION THROUGH LYSOZYME-CATALYZED TRANSFER REACTION

A hen egg-white lysozyme produced regioselectively 4-O-(2-acetamido-2-deoxy-β-D-glucopyranosyl)-D-mannose and p-nitrophenyl 4-O-(2-acetamido-2-deoxy-β-D-glucopyranosyl)-β-D-mannopyranoside through a transglycosylation reaction from N,N'-diacetylchitobiose and respectively mannose and p-nitrophenyl β-D-mannopyranoside.These enzyme reactions were efficient enough to allow the one-pot preparation of the desired disaccharide.When p-nitrophenyl 2-acetamido-2-deoxy-α-D-glucopyranoside was the acceptor, the enzyme catalyzed the formation of a β-(1-3)-linked disaccharide glycoside (p-nitrophenyl 2-acetamido-2-deoxy-3-O-(2-acetamido-2-deoxy-β-D-glucopyranosyl)-α-D-glucopyranoside) with its β-(1-4)-linked isomer.This is also the case for the formation of p-nitrophenyl 3-O-(2-acetamido-2-deoxy-β-D-glucopyranosyl)-α-maltoside with p-nitrophenyl α-maltoside acceptor.The results show that the anomeric configuration of the glycosidic linkage in the glycosyl acceptors had a pronounced effect on the position of transglycosylation.