145656-46-8Relevant articles and documents
Oxidation of Aphidicolin and Its Conversion into 19-Noraphidicolan-16β-ol
Gordon, John F.,Hanson, James R.,Jarvis, Andrew G.,Ratcliffe, Arnold H.
, p. 3019 - 3022 (2007/10/02)
The preparation of the 3α,18-monoacetonide of aphidicolin and its selective oxidation at C-17, is described.Catalytic oxidation of aphidicolin affords 16β-hydroxy-3-oxo-19-noraphidicolan-17-oic acid.The conversion of this into 19-noraphidicolan-16β-ol and its biotransformation by the fungus, Cephalosporium aphidicola, to a 19-noraphidicolin, is reported.