145665-81-2

Upstream product

• 145665-70-9 4-Acetylamino-3-nitro-benzoic acid 2-acetyl-phenyl ester 
• 1539-06-6 3-nitro-4-acetamidobenzoic acid 
• 556-08-1 p-(acetylamino)benzoic acid 
• 150-13-0 4-amino-benzoic acid 
• 118-93-4 o-hydroxyacetophenone 

Downstream Products

• 145665-92-5 3-bromo-2-(4'-acetamido-3'-nitrophenyl)flavone 
• 170804-62-3 2-(4-acetylamino-3-nitrophenyl)-4H-1-benzopyran-4-one 
• 1026970-49-9 N-[2-Amino-4-(4-oxo-4H-chromen-2-yl)-phenyl]-acetamide 

Relevant academic research and scientific papers

Synthesis and antiaggregator activity of some new derivatives of 4H-benzopyran-4-one

A series of 2--4H-1-benzopyran-4-one analogues 7a-7e was synthesized by the reaction with 3',4'-diaminoflavone and aliphatic carboxylic acids. 3',4'-Diaminoflavone 6 was prepared via the reduction of 2-(4-amino-3-nitrophenyl)-4H-1-benzopyran-4-one 5a.The compounds 7a-e and 14a-f were tested in vitro for their inhibitory activities against human platelet aggregation induced by collagen, ADP and A23187.The compound with a COOR group as a side chain, 2-(2-akyloxycarbonyl-2,3-dihydro-1,4-benzodioxin -6-yl)-4H-1-benzopyran-4-one 14a-f, haspotent activity, and so compound 13 was also prepared as an analogue of series 14 and tested for its antiaggregator activity. 4H-1-benzopyran-4-one/ benzodioxane/ benzimidazole/ human platelet/ aggregation

Syntheses of some 2-(4'-Acetamido-3'-nitrobenzoyl)coumaran-3-ones

Syntheses of several 2-(4'-acetamido-3'-nitrobenzoyl)coumaran-3-ones by two routes have been described.In one, the corresponding esters were converted to the related 1,3-diketones which on bromination directly produced 3-bromoflavones.Refluxing of the bro