1456809-37-2

Upstream product

• 2374-05-2 4-bromo-2,6-dimethyl-phenol 
• 1456809-35-0 5-bromo-2-((2-methoxyethoxy)methoxy)-1,3-dimethylbenzene 
• 1066-54-2 trimethylsilylacetylene 

Downstream Products

• 1456809-34-9 7-hydroxy-3-((4-hydroxy-3,5-dimethylphenyl)ethynyl)-4-methyl-2H-chromen-2-one 
• 1456809-38-3 5-ethynyl-2-((2-methoxyethoxy)methoxy)-1,3-dimethylbenzene 
• 1456809-42-9 3-((4-((2-methoxyethoxy)methoxy)-3,5-dimethylphenyl)ethynyl)-4-methyl-2H-chromen-2-one 
• 1456809-43-0 6-methoxy-3-((4-((2-methoxyethoxy)methoxy)-3,5-dimethylphenyl)ethynyl)-4-methyl-2H-chromen-2-one 
• 1456809-30-5 3-((4-hydroxy-3,5-dimethylphenyl)ethynyl)-4-methyl-2H-chromen-2-one 
• 1456809-31-6 (E)-3-(4-hydroxy-3,5-dimethylstyryl)-7-methoxy-4-methyl-2H-chromen-2-one 
• 1456809-32-7 3-((4-hydroxy-3,5-dimethylphenyl)ethynyl)-7-methoxy-4-methyl-2H-chromen-2-one 
• 1456809-33-8 6-hydroxy-3-((4-hydroxy-3,5-dimethylphenyl)ethynyl)-4-methyl-2H-chromen-2-one 

Relevant academic research and scientific papers

Systemic optimization and structural evaluation of quinoline derivatives as transthyretin amyloidogenesis inhibitors

Wild type transthyretin (TTR) and mutant TTR misfold and misassemble into a variety of extracellular insoluble amyloid fibril and/or amorphous aggregate, which are associated with a variety of human amyloid diseases. To develop potent TTR amyloidogenesis

Bifunctional coumarin derivatives that inhibit transthyretin amyloidogenesis and serve as fluorescent transthyretin folding sensors

We describe coumarin derivatives that are non-fluorescent in aqueous buffers and that very selectively bind to transthyretin (TTR) in complex biological environments potently inhibiting TTR amyloidogenesis while also exhibiting sensitive off-on fluorescen