1456882-29-3Relevant academic research and scientific papers
Catalyst-controlled aliphatic c-h oxidations with a predictive model for site-selectivity
Gormisky, Paul E.,White, M. Christina
, p. 14052 - 14055 (2013/10/21)
Selective aliphatic C-H bond oxidations may have a profound impact on synthesis because these bonds exist across all classes of organic molecules. Central to this goal are catalysts with broad substrate scope (small-molecule-like) that predictably enhance or overturn the substrate's inherent reactivity preference for oxidation (enzyme-like). We report a simple small-molecule, non-heme iron catalyst that achieves predictable catalyst-controlled site-selectivity in preparative yields over a range of topologically diverse substrates. A catalyst reactivity model quantitatively correlates the innate physical properties of the substrate to the site-selectivities observed as a function of the catalyst.
