1456889-41-0Relevant academic research and scientific papers
Rapid access to the synthesis of polysubstituted δ-lactones via tandem stereoselective conjugate addition/α-alkylation of unsaturated 7,3-lactone-α-d-xylofuranose derivative
Ramírez, Elsie,Quintero, Leticia,Meza-León, Rosa L.,Sosa-Rivadeneyra, Martha,Cruz-Gregorio, Silvano,Sartillo-Piscil, Fernando
, p. 5751 - 5754 (2013)
α-d-xylo-7,3-Unsaturated lactone, a versatile chiral building block, undergoes Cu-catalyzed conjugated addition with high yield and stereoselectivity. When the conjugated reaction is quenched with a suitable alkyl halide, a tandem stereoselective conjugated/α-alkylation reaction is achieved. Further, selective hydrolysis of the 1,2-O-isopropylidene moiety followed by oxidative cleavage and reduction reaction, afforded the title compounds.
