1456904-95-2Relevant academic research and scientific papers
Cu-Catalyzed alkynylation-cyclization cascade for the construction of the pyrazolo[5,1-a]isoquinoline skeleton
Yang, Yanfang,Ren, Hailong,Wang, Dongyang,Shi, Feng,Wu, Chunrui
, p. 10434 - 10441 (2013/09/02)
A Cu-catalyzed Sonogashira-type coupling of 3-(2-bromophenyl)pyrazoles with terminal alkynes combined with a subsequent electrophilic cyclization in the same pot was developed to afford pyrazolo[5,1-a]isoquinolines. The transformation proceeds without the necessity of using Pd or ligands, while an Ag additive is beneficial. The Royal Society of Chemistry 2013.
