1457-48-3

Usage

Ketone derivative

A ketone derivative is a compound derived from ketones, which are organic compounds containing a carbonyl group (C=O) bonded to two carbon atoms. In this case, 1-phenyl-2-(1H-pyrazol-1-yl)Ethanone has a carbonyl group attached to a phenyl group and a pyrazole ring.

Phenyl group

A phenyl group is a carbon-based functional group consisting of a six-membered aromatic ring with five hydrogen atoms and one substituent attached to it. In 1-phenyl-2-(1H-pyrazol-1-yl)Ethanone, the phenyl group is attached to the carbonyl group.

Pyrazole ring

A pyrazole ring is a five-membered aromatic heterocyclic compound consisting of three carbon atoms and two nitrogen atoms. In 1-phenyl-2-(1H-pyrazol-1-yl)Ethanone, the pyrazole ring is attached to the same carbon atom as the phenyl group.

Building block in organic synthesis

1-phenyl-2-(1H-pyrazol-1-yl)Ethanone is used as a starting material or intermediate in the synthesis of more complex organic compounds, making it a valuable component in organic chemistry.

Pharmaceutical research

The compound has potential applications in the development of new drugs and biologically active compounds, making it an important subject of study in pharmaceutical research.

Unique chemical properties

The presence of both the phenyl and pyrazole groups in the structure of 1-phenyl-2-(1H-pyrazol-1-yl)Ethanone gives it unique chemical properties, which can be exploited in the synthesis of various organic compounds.

Valuable intermediate

Due to its unique chemical properties and potential applications, 1-phenyl-2-(1H-pyrazol-1-yl)Ethanone is considered a valuable intermediate for the synthesis of a wide range of organic compounds.

Upstream product

• 288-13-1 NH-pyrazole 
• 532-27-4 1-chloroacetophenone 
• 13735-81-4 1-styrenyloxytrimethylsilane 
• 70-11-1 α-bromoacetophenone 

Downstream Products

• 32500-66-6 1-<(2'-hydroxy-2'-phenylethyl)>pyrazole 

Relevant academic research and scientific papers

Preliminary structure-activity relationship (SAR) of a novel series of pyrazole SKF-96365 analogues as potential store-operated calcium entry (SOCE) inhibitors

From a series of (1R, 1S)-1[β-(phenylalkoxy)-(phenetyl)]-1H-pyrazolium hydrochloride as new analogues of SKF-96365, one has an interesting effect for endoplasmic reticulum (ER) Ca2+ release and store-operated Ca2+ entry (SOCE) (ICsu

Nickel-Catalyzed Tandem Knoevenagel Condensation and Intramolecular Direct Arylation: Synthesis of Pyrazolo[5,1-a]-isoquinoline Derivatives

A simple and efficient method for the synthesis of pyrazolo[5,1-a]isoquinoline derivatives has been developed using the nickel-catalyzed reaction of 1-aryl-2-(1H-pyrazol-1-yl)ethan-1-ones and 2-bromo aldehydes. The overall transformation involves tandem K

α-N-Heteroarylation and α-Azidation of Ketones via Enolonium Species

Enolonium species, resulting from the umpolung of ketone enolates by Koser's hypervalent iodine reagents activated by boron trifluoride, react with a variety of nitrogen heterocycles to form α-aminated ketones. The reactions are mild and complete in 4-5 h. Additionally, α-azidation of the enolonium species takes place using trimethylsilyl azide as a convenient source of azide nucleophile.

ARALKYL AMINES AS CANNABINOID RECEPTOR MODULATORS

Novel compounds of the structural formula (I) are antagonists and/or inverse agonists of the Cannabinoid-1 (CB1) receptor and are useful in the treatment, prevention and suppression of diseases mediated by the CB1 receptor. The compounds of the present invention are useful as centrally acting drugs in the treatment of psychosis, memory deficits, cognitive disorders, migraine, neuropathy, neuro-inflammatory disorders including multiple sclerosis and Guillain-Barre syndrome and the inflammatory sequelae of viral encephalitis, cerebral vascular accidents, and head trauma, anxiety disorders, stress, epilepsy, Parkinson’s disease, movement disorders, and schizophrenia. The compounds are also useful for the treatment of substance abuse disorders, including alcohol and nicotine addiction, the treatment of obesity or eating disorders, as well as the treatment of asthma, constipation, chronic intestinal pseudo-obstruction, and cirrhosis of the liver.