145731-72-2Relevant academic research and scientific papers
Tailor-Made Host for Piperazine and Related Amines
Hoss, Ralf,Voegtle, Fritz
, p. 1003 - 1010 (2007/10/02)
The 38-membered bis-catechol 4b is obtained by cyclisation of the diacyl dichloride 3c with the diamine 2b in 45percent yield, whereas a 68-membered octalactam 7 is formed under similar conditions from 5 and 1b.Bis-catechol 4b is a selective host compound for piperazine (8) and the structurally related diamine 9.Association constants for the 1:1 complexes have been measured by 1H NMR titration experiments.A nucleobase guest (pterine, 24) was extracted into a hydrochloric acid phase by complex formation with the host 4b.The results are compared with solubility and transport experiments obtained by use of analogous macrobicyclic tris-catechol hosts.Key Words: Diamine / Host-guest chemistry / Macrocycle / Supramolecular chemistry / Receptor molecule, synthetic
Synthetic Molecular Raceptor for Piperazine and Related Diamines
Voegtle, Fritz,Hoss, Ralf
, p. 1584 - 1585 (2007/10/02)
The new tailored tetrahydroxycyclophane 4b is shown to be a selective host compound for piperazine 6 and structurally related diamines 7 and 8; association constants for the 1:1 complexes have been measured by 1H NMR titration experiments.
