145733-77-3Relevant academic research and scientific papers
Conversion of epoxides into halohydrins with elemental halogen catalyzed by thiourea
Sharghi, Hashem,Eskandari, Mohammad Mehdi
, p. 8509 - 8514 (2003)
A highly regioselective method for the synthesis of β-iodohydrins and β-bromohydrins by the direct ring opening of epoxides with elemental halogen in the presence of thiourea is described. This method occurs under neutral and mild conditions with high yields in various solvents even when sensitive functional groups are present.
Visible-light-triggered Catalytic Halohydrin Synthesis from Epoxides and Trichloroacetonitrile by Copper and Iron Salts
Toda, Yasunori,Tanaka, Katsumi,Matsuda, Riki,Suga, Hiroyuki
supporting information, p. 1469 - 1471 (2019/12/02)
Preparation of vicinal halohydrins, in which copper or iron chlorides catalyze the ring-opening reaction of epoxides with visible light effectively, is described. The use of trichloroacetonitrile as a halogen source enables catalytic HCl generation under the mild conditions. This method can also be applied to the aziridine ring-opening reaction.
