14576-22-8

Usage

Explanation

The compound is composed of 11 carbon atoms, 11 hydrogen atoms, 1 nitrogen atom, and 2 oxygen atoms.

Explanation

The compound is a derivative of isoquinolinedione with an amino group at the 7th position and two methyl groups at the 4th position.

Explanation

Due to its specific chemical structure, the compound has potential pharmacological and biological activities, making it a subject of interest for further investigation.

Explanation

The compound is used in the development of new drugs, as its unique structure may provide novel therapeutic properties.

Explanation

The compound is used in biochemical studies to understand its interactions with biological systems, which can help in the development of targeted therapies.

Explanation

The compound's properties and potential applications make it a valuable subject for further investigation and development in the fields of pharmaceuticals and biotechnology.

Explanation

The compound is derived from isoquinolinedione, which is a bicyclic organic compound with a core structure of two six-membered rings fused together.

Explanation

The compound contains an amino group (-NH2) at the 7th position, which can participate in various chemical reactions and interactions.

Explanation

The compound has two methyl groups (-CH3) attached to the 4th position of the isoquinolinedione core, which can influence its chemical properties and reactivity.

Explanation

The compound's unique structure and potential pharmacological activities make it a promising candidate for the development of new drugs targeting various diseases and conditions.

Chemical Structure

1,3(2H,4H)-Isoquinolinedione, 7-amino-4,4-dimethyl-

Amino Group

7-amino

Methyl Groups

4,4-dimethyl

Upstream product

• 14576-21-7 4,4-dimethyl-7-nitro-2H-3,4-dihydro-isoquinolin-1,3-dione 
• 5488-36-8 4,4-dimethyl-4H-isoquinoline-1,3-dione 
• 99911-10-1 2-(2-cyanopropan-2-yl)benzonitrile 

Downstream Products

• 859826-71-4 1,2,3,4-tetrahydro-4,4-dimethylisoquinolin-7-amine 
• 1026910-04-2 1-(8-amino-4,4-dimethyl-1,3-dioxo-1,2,3,4-tetrahydro-isoquinolin-7-yl)-3-(2,3,5,6-tetrachloro-phenyl)-thiourea 
• 1026270-01-8 1-(8-amino-4,4-dimethyl-1,3-dioxo-1,2,3,4-tetrahydro-isoquinolin-7-yl)-3-(2,4,6-trichloro-phenyl)-thiourea 
• 1027961-53-0 1-(8-amino-4,4-dimethyl-1,3-dioxo-1,2,3,4-tetrahydro-isoquinolin-7-yl)-3-(2,4-dichloro-phenyl)-thiourea 
• 1027266-81-4 1-(8-amino-4,4-dimethyl-1,3-dioxo-1,2,3,4-tetrahydro-isoquinolin-7-yl)-3-(2,6-difluoro-phenyl)-thiourea 
• 1027556-48-4 1-(8-amino-4,4-dimethyl-1,3-dioxo-1,2,3,4-tetrahydro-isoquinolin-7-yl)-3-(2-chloro-6-methyl-phenyl)-thiourea 
• 333458-24-5 1-(8-amino-4,4-dimethyl-1,3-dioxo-1,2,3,4-tetrahydroisoquinolin-7-yl)-3-(2,6-dichlorophenyl)thiourea 
• 1026277-31-5 1-(8-amino-4,4-dimethyl-1,3-dioxo-1,2,3,4-tetrahydro-isoquinolin-7-yl)-3-(4-chloro-phenyl)-thiourea 
• 333455-11-1 2-(2,6-Dichlorophenylamino)-6,7-dimethyl-1,8-dihydro-imidazo[4,5-h]isoquinoline-9-one 
• 333458-25-6 2-(2,6-dichloro-phenylamino)-7-hydroxy-6,6-dimethyl-1,6,7,8-tetrahydro-imidazo[4,5-h]isoquinolin-9-one 
• 333455-06-4 2-(2,6-Dichlorophenylamino)-6,6-dimethyl-1H,6H-imidazo[4,5-h]isoquinoline-7,9-dione 

Relevant academic research and scientific papers

Discovery of 2-phenylamino-imidazo[4,5-h]isoquinolin-9-ones: A new class of inhibitors of lck kinase

An imidazo[4,5-h]isoquinolin-7,9-dione (1) was identified as an adenosine 5′-triphosphate competitive inhibitor of lck by high throughput screening. Initial structure-activity relationship studies identified the dichlorophenyl ring and the imide NH as important pharmacophores. A binding model was constructed to understand how 1 binds to a related kinase, hck. These results suggested that removing the gem-dimethyl group and flattening the ring would enhance activity. This was realized by converting 1 to the imidazo[4,5-h]isoquinolin-9-one (20), resulting in an 18-fold improvement in potency against lck and a 50-fold increase in potency in a cellular assay.