145795-76-2Relevant academic research and scientific papers
Cat-1 inhibitors, pharmaceutical compositions and methods of use
-
, (2008/06/13)
The invention relates to compounds of the formula STR1 wherein R1, R2, R2 ' X, Y, Z, A, B, Q and n are as described herein. Their pharmaceutically acceptable salts, and when appropriate, enantiomers, racemates, diastereomers or mixtures thereof or geometric isomer or mixtures thereof, and pharmaceutically acceptable salts thereof. The compounds of formula I inhibit enzyme carnitine acyltransferase 1 (CAT-1) and are therefore useful in the prevention of injury to ischemic tissue, and can limit infarct size, improve cardiac function and prevent arrhythmias during and following a myocardial infarction.
