145829-53-4Relevant academic research and scientific papers
Phenyl pyrazolidinones as bronchodilators and anti-inflammatory agents
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, (2008/06/13)
There are disclosed compounds of the formula STR1 wherein R1 is hydrogen or lower alkyl; R2 is C3-7 alkyl or C3-7 cycloalkyl; R3 is hydrogen, lower alkyl, carboxyloweralkyl, lower alkoxycarbonyl, lower alkoxycarbonyl loweralkyl, aryl or aralkyl; R4 is hydrogen, C1-8 alkyl, STR2 B is a bond, NH or O; Y is O or S; A is a bond or --C=C--; n is 0-5; R5 is hydrogen when B is NH, or R5 is lower alkyl, C3-8 cycloalkyl; aryl, substituted aryl, aralkyl, substituted aralkyl, aralkenyl, aralkenylalkyl or STR3 R6 is hydrogen or halo; the dotted line represents an optional double bond; and the pharmacologically acceptable salts thereof, which by virtue of their ability to selectively inhibit PDE IV, are bronchodilatory and anti-inflammatory and so are useful in the treatment of acute and chronic bronchial asthma and associated pathologies.
