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145837-65-6

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145837-65-6 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 145837-65-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,4,5,8,3 and 7 respectively; the second part has 2 digits, 6 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 145837-65:
(8*1)+(7*4)+(6*5)+(5*8)+(4*3)+(3*7)+(2*6)+(1*5)=156
156 % 10 = 6
So 145837-65-6 is a valid CAS Registry Number.

145837-65-6SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name imidazo[1,5-a][1,3,5]triazin-4-amine

1.2 Other means of identification

Product number -
Other names 4-aminoimidazo<1,5-a>-1,3,5-triazine

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:145837-65-6 SDS

145837-65-6Relevant articles and documents

The Synthesis of Heterocycles via Addition-Elimination Reactions of 4- and 5-Aminoimidazoles

Al-Shaar, Adnan H. M.,Chambers, Robert K.,Gilmour, David W.,Lythgoe, David J.,McClenaghan, Ian,Ramsden, Christopher A.

, p. 2789 - 2812 (2007/10/02)

4-Aminoimidazoles 1 undergo addition-elimination reactions with the electrophilic reagents 5-12 to give exclusively N-adducts, which are useful intermediates for further synthetic transformations to novel heterocyclic systems.Diethyl ethoxymethylenemalonate 5 and 4-amino-1-benzylimidazole 1g give the adduct 13g and subsequent acid-catalysed cyclisation gives the imidazopyridine 25 and the heterocyclic mesomeric betaine 26 which undergoes 1,3-dipolar cycloaddition with dimethyl acetylenedicarboxylate to give two products 29 and 30.When the 2-alkyl-4-aminoimidazoles 1b-d are generated in situ in the presence of the reagent 5, signi ficant products are the 5,5'-diimidazoles 15 and a mechanism for this novel transformation is proposed. 4-Amino-3-cyano-imidazopyrimidines 40 and 41 are formed by cyclisation of the N-adducts prepared using ethoxymethylenemalononitriles 6 and 7.Ethoxymethyleneurethane 9 gives the adducts 66 and cyclisation of the parent adduct 66a gives the novel imidazo-1,3,5-triazin-4-one 68a, the potassium salt of which undergoes N-alkylation.The use of the reagents 10-12 leads to novel 4-aminoimidazo-1,3,5-triazine derivatives 72 whose chemical reactions with both electrophilic and nucleophilic reagents are reported. 5-Aminoimidazoles 3 undergo addition-elimination reactions with the electrophilic reagents 5-12 to give N-adducts and/or C-adducts, depending upon the structure of the reagent.These stable addition-elimination products are usually obtained in good yield and are useful intermediates for further synthesis.Reaction of the amines 3 with diethyl ethoxymethylenemalonate 5 gives mainly N-adducts 17 which can be cyclised using phosphoryl chloride to give the versatile 7-chloroimidazopyridines 31.With ethoxymethylenemalononitrile 6 the amines 3 give C-adducts 42.Thermal cyclisa tion of these adducts 42 gives 5-amino-6-cyanoimidazopyridines 43 which are transformed into novel heterocyclic systems including the tricyclic imidazopyridopyrimidines 55.Cyclisation of the adducts obtained using ethoxymethyleneurethane 9 and the N-cyano analogues 10 and 12 provides new synthetic routes to amino-purine derivatives 86 and 87 and hypoxanthines 70.The preference of electrophilic reagents for N- or C-addition to 5-aminoimidazoles 3 is rationalised using Frontier Molecular Orbital theory.

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