145839-07-2Relevant academic research and scientific papers
3 and 5 alkyl and phenyl 4-(hydroxy or acyloxy)-alkyl substituted 2(5H)-furanones as anti-inflammatory agents
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, (2008/06/13)
Novel anti-inflammatory furanone compounds have the following formula: STR1 where R1 independently is H, or alkyl of 1 to 9 carbons and n is an integer having the values of 1 or 2, and where when n is 1 the R1 group is attached to th
Pharmaceutical compositions and method for administering 3 and 4-substituted 2(5H)-furanones to a mammal for inhibiting bone loss
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, (2008/06/13)
3 and 4-substituted 2(5H)-furanone compounds influence the balance between bone production and bone resorption in mammals, including humans. The active compounds are administered to mammals, including humans, in an effective dose which ranges between 0.05 to 100 mg per kilogram, body weight, per day, for the purpose of influencing the balance between bone production and bone resorption, and particularly for treating osteoporosis.
Intermediates and processes for preparing 4-substituted 2-5(H)-furanones as anti-inflammatory agents
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, (2008/06/13)
Anti-inflammatory 4-substituted 2-furanones are made from intermediates having the formulas: STR1 in which R1, R2 and R3 independently are n-alkyl of 1 to 6 carbons, or branched chain alkyl of 1 to 6 carbons; X is H, OH, NH2, I or Br; R4 is H, alkyl of 1-20 carbons, phenyl[C1 -C20 alkyl], naphthyl[C1 -C20 alkyl], CH2 OH, CH2 NH2, CH2 CH2 OH, CH2 --CHO, CH2 --COOH or CH2 --COOR5, and R5 is alkyl of 1 to 6 carbons, with the proviso that when X is hydrogen then R4 is selected from the group consisting of CH2 OH, CH2 NH2, CH2 CH2 OH, CH2 --CHO, or CH2 --COOR5 ; STR2 in which R1, R2 and R3 independently are n-alkyl of 1 to 6 carbons, or branched chain alkyl or 1 to 6 carbons, and R5 is alkyl or 1 to 6 carbons; STR3 in which R1, R2 and R3 independently are n-alkyl of 1 to 6 carbons, or branched chain alkyl of 1 to 6 carbons, and R6 is phenyl, or alkyl of 1 to 6 carbons, and STR4 in which R1, R2 and R3 independently are n-alkyl of 1 to 6 carbons, or branched chain alkyl of 1 to 6 carbons.
