1458652-41-9Relevant academic research and scientific papers
A benzo furazane derivatives as anti-plant pathogenic fungi in the application of the medicament
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Paragraph 0055; 0056; 0057, (2016/12/01)
The invention provides an application of benzofuroxan derivatives to medicines resisting plant pathogenic fungi. According to the invention, the benzofuroxan derivatives are used for resisting plant pathogenic fungi, and compounds with good activities are
Benzofurazan derivatives as antifungal agents against phytopathogenic fungi
Wang, Lili,Zhang, Ying-Ying,Wang, Lei,Liu, Feng-You,Cao, Ling-Ling,Yang, Jing,Qiao, Chunhua,Ye, Yonghao
, p. 535 - 542 (2014/06/09)
A series of benzofurazan derivatives were prepared and evaluated for their biological activities against four important phytopathogenic fungi, namely, Rhizoctonia solani, Sclerotinia sclerotiorum, Fusarium graminearum and Phytophthora capsici, using the mycelium growth inhibition method. The structures of these compounds were characterized by1H NMR,13C NMR, and HRMS. N-(3-chloro-4-fluorophenyl)-7-nitrobenzo[c][1,2,5] oxadiazol-4-amine (A3) displayed the maximum antifungal activity against R. solani (IC50= 1.91 μg/mL), which is close to that of the positive control Carbendazim (IC50= 1.42 μg/mL). For other benzofurazan derivatives with nitro group at R4position (A series), 9 out of 30 compounds exhibited high antifungal effect against strain R. solani, with IC50values less than 5 μg/mL. Most of the derivatives with substituents at R2and R3positions (B series) displayed moderate growth inhibition against S. sclerotiorum (IC504position and another conjugated aromatic ring at the R1position of the phenyl ring displayed high antifungal capability against strain R. solani. Compounds with substituents at R2and R3position had moderate efficacy against strain S. sclerotiorum.
Discovery and synthesis of novel benzofurazan derivatives as inhibitors of influenza A virus
Kessler, Ulrich,Castagnolo, Daniele,Pagano, Mafalda,Deodato, Davide,Bernardini, Martina,Pilger, Beatrice,Ranadheera, Charlene,Botta, Maurizio
supporting information, p. 5575 - 5577 (2013/10/01)
The identification of a novel hit compound inhibitor of the protein-protein interaction between the influenza RNA-polymerase PA and PB1 subunits has been accomplished by means of high-throughput screening. A small family of structurally related molecules
