1458714-49-2Relevant academic research and scientific papers
Cascade reaction synthesis of multisubstituted bicyclic pyridone derivatives
Chen, Xuebing,Zhu, Dandan,Wang, Xiaoying,Yan, Shengjiao,Lin, Jun
, p. 9224 - 9236 (2013/10/01)
An efficient synthesis of novel bicyclic pyridone derivatives via cascade reaction of heterocyclic ketene aminals (HKAs) and 4-arylmethylene-2- phenyloxazol-5(4H)-ones in the presence of acetic acid has been established. Significantly, the protocol affords a straightforward approach to the construction of multisubstituted bicyclic pyridones in which one C-O bond was cleaved and new C-C and C-N bonds were formed in one pot under mild conditions.
