1458726-10-7

Basic information

• Product Name: C₁₃H₁₈N₂O
• Synonyms: C₁₃H₁₈N₂O
• CAS NO: 1458726-10-7
• Molecular Weight: 218.299
• Mol File: 1458726-10-7.mol

Chemical Properties

• CAS DataBase Reference: C₁₃H₁₈N₂O(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₃H₁₈N₂O(1458726-10-7)
• EPA Substance Registry System: C₁₃H₁₈N₂O(1458726-10-7)

Safety Data

• Hazardous Substances Data: 1458726-10-7(Hazardous Substances Data)

Upstream product

• 555-16-8 4-nitrobenzaldehdye 
• 1598408-70-8 C₁₃H₁₄N₂O₃ 
• 61921-33-3 p-nitrocinnamoyl chloride 
• 619-89-6 p-nitrocinnamic acid 

Downstream Products

• 1598408-33-3 1-(4-(2-(cyclobutylcarbamoyl)ethyl)phenyl)-3-(4-chloro-3-(trifluoromethyl)phenyl)urea 

Relevant articles and documents

Design, synthesis and evaluation of novel diaryl urea derivatives as potential antitumor agents

A novel series of diaryl ureas containing different linker groups were designed and synthesized. Their in vitro antitumor activity against MX-1, A375, HepG2, Ketr3 and HT-29 was evaluated using the standard MTT assay. Compounds having a rigid linker group such as vinyl, ethynyl and phenyl showed significant inhibitory activity against a variety of cancer cell lines. Specifically, compound 23 with a phenyl linker group demonstrated broad-spectrum antitumor activity with IC50 values of 5.17-6.46 μM against five tested tumor cell lines. Compound 23 is more potent than reference drug sorafenib (8.27-15.2 μM), representing a promising lead for further optimization.