14590-53-5

Basic information

• Product Name: (S)-(+)-2,2-DIMETHYLCYCLOPROPANE CARBOXYLIC ACID
• Synonyms: (S)-(+)-2,2-DIMETHYLCYCLOPROPANE CARBOXYLIC ACID;(S)-2,2-DIMETHYLCYCLOPROPANECARBOXYLIC ACID;(S)-(+)-DMCPCA;(S)-(+)-2,2-Dimethylcyclopropanecarboxylic Acid
• CAS NO: 14590-53-5
• Molecular Formula: C₆H₁₀O₂
• Molecular Weight: 114.139999389648
• Product Categories: Carboxylic Acids (Chiral);Chiral Building Blocks;Cyclopropanes;Simple 3-Membered Ring Compounds;Synthetic Organic Chemistry
• Mol File: 14590-53-5.mol
• Article Data: 11

Chemical Properties

• Boiling Point: 100 °C / 12mmHg
• Flash Point: 83.357 °C
• Appearance: /
• Density: 0.99
• Vapor Pressure: 0.339mmHg at 25°C
• Refractive Index: 124 ° (C=1, MeOH)
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 4.99±0.22(Predicted)
• CAS DataBase Reference: (S)-(+)-2,2-DIMETHYLCYCLOPROPANE CARBOXYLIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-(+)-2,2-DIMETHYLCYCLOPROPANE CARBOXYLIC ACID(14590-53-5)
• EPA Substance Registry System: (S)-(+)-2,2-DIMETHYLCYCLOPROPANE CARBOXYLIC ACID(14590-53-5)

Safety Data

• Hazardous Substances Data: 14590-53-5(Hazardous Substances Data)

Usage

General Description

(S)-(+)-2,2-DIMETHYLCYCLOPROPANE CARBOXYLIC ACID is a chemical compound with the molecular formula C7H12O2. It is a carboxylic acid, which means it contains a carboxyl group (COOH). (S)-(+)-2,2-DIMETHYLCYCLOPROPANE CARBOXYLIC ACID is a chiral molecule, meaning it has a non-superimposable mirror image, or enantiomer. It is commonly used as a chiral building block in organic synthesis, particularly in the production of pharmaceuticals and agrochemicals. Its unique structure and properties make it useful in creating new and complex molecules, and it is often sought after for its potential in drug development and large-scale manufacturing processes.

InChI:InChI=1/C6H10O2/c1-6(2)3-4(6)5(7)8/h4H,3H2,1-2H3,(H,7,8)/t4-/m1/s1

Upstream product

• 1759-55-3 (RS)-2,2-dimethylcyclopropanecarboxamide 
• 16783-11-2 ethyl (±)-2,2-dimethylcyclopropanecarboxylate 
• 645413-67-8 2,2-dimethylcyclopropane carboxylic acid 2,2,2-trifluoroethyl ester 
• 167482-50-0 1,2-O-Isopropylidene-3-O-(p-phenylbenzyl)-4,5-O-<(1'R)-3'-methyl-2'-buten-1'-yl>-β-D-fructopyranose 
• 1740-74-5 1,1-diethoxy-3-methyl-2-butene 
• 75885-58-4 (S)-2,2-dimethylcyclopropanecarboxamide 
• 75885-59-5 2,2-dimethylcyclopropane-1-carboxylic acid 

Downstream Products

• 67911-21-1 cis-caronic anhydride 
• 82009-34-5 cilastatine 
• 85394-14-5 (+)-(Z)-2-(2,2-dimethylcyclopropanecarboxamido)-2-octenoic acid 
• 75885-58-4 (S)-2,2-dimethylcyclopropanecarboxamide 

Relevant articles and documents

The synthesis of S-(+)-2,2-dimethylcyclopropane carboxylic acid: A precursor for cilastatin

S-(+)-2,2-Dimethylcyclopropane carboxylic acid, a precursor for cilastatin, was prepared from 2-methylpropene and chiral iron carbene in three steps. Asymmetric cyclopropanation reaction of 2-methylpropene with iron carbene complex having chirality at the carbene ligand, followed by exhaustive ozonolysis, produced S-(+)-2,2-dimethylcyclopropanecarboxylic acid of up to 92% ee. The absolute configuration of complexed chiral cyclopropane (-)-8 was determined by X-ray crystallographic analysis.

Soluble and functional expression of a recombinant enantioselective amidase from Klebsiella oxytoca KCTC 1686 in Escherichia coli and its biochemical characterization

A gene encoding an enantioselective amidase (KamH) was cloned from Klebsiella oxytoca KCTC 1686 and inserted into the EcoRI and HindIII sites of the vector pET-30a(+). When KamH with a peptide containing a His-tag and an enterokinase cleavage site was overexpressed in Escherichia coli, approximately half was found in the soluble fraction, but it lacked activity. After cleavage of the peptide by enterokinase, the enzyme activity was partly restored, reaching 420.2 ± 33.62 U/g dry cell weight (DCW). Another recombinant plasmid was constructed by inserting the KamH gene into the NdeI and EcoRI sites of pET-30a(+) to express KamH in its native form. The overexpressed amidase was found primarily in the soluble fraction and its maximum activity was 3613.4 ± 201.68 U/g DCW. This indicated that the peptide influenced not only soluble expression but also activity of KamH, perhaps by blocking the substrate-binding tunnel of KamH. Similar results were obtained with heterologously expressed amidases from Rhodococcus erythropolis MP50 and Agrobacterium tumefaciens d3. All of these amidases have an N-terminal α-helical domain. Therefore, amidases of this type may be functionally expressed in their native form. KamH hydrolyzed a range of aliphatic and aromatic amides and exhibited strict S-selectivity towards racemic amides.

Production of L-tryptophan by enantioselective hydrolysis of d,l-tryptophanamide using a newly isolated bacterium

Bacterial strain ZJB-09211 capable of amidase production has recently been isolated from soil samples. The strain is able to asymmetrically hydrolyze l-tryptophanamide from d,l-tryptophanamide to produce l-tryptophan in high yield and with excellent stereoselectivity (enantiomeric excess > 99.9 %, and enantiomeric ratio > 200). Strain ZJB-09211 has been identified as Flavobacterium aquatile based on the cell morphology analysis, physiological tests, and the 16S rDNA sequence analysis. Optimization of the fermentation medium led to an about six-fold increase in the amidase activity of strain ZJB-09211, which reached 501.5 U L-1. Substrate specifity and stereoselectivity investigations revealed that amidase of F. aquatile possessed a broad substrate spectrum and high enantioselectivity.

PROCESS FOR PRODUCING OPTICALLY ACTIVE AMIDE

The present invention relates to a new process for preparing a medical intermediate compound of formula (I). According to the present invention, an intermediate compound for cilastatin can be simply prepared with a high yield of 99.0% or more and a high optical purity of 99.5% without undergoing any dangerous processes.