145910-07-2

Upstream product

• 18162-48-6 tert-butyldimethylsilyl chloride 
• 127154-84-1 tert-butylpent-4-enyloxydimethylsilane 
• 92-71-7 2,5-diphenyloxazole 
• 87184-81-4 4-(tert-butyldimethylsilanyloxy)butanal 

Downstream Products

• 145910-02-7 N-Benzoyl-N-[2-benzyloxy-5-(tert-butyl-dimethyl-silanyloxy)-pentanoyl]-benzamide 
• 145910-03-8 α-benzyloxy δ-valerolactone 
• 145910-01-6 4-[1-Benzyloxy-4-(tert-butyl-dimethyl-silanyloxy)-butyl]-2,5-diphenyl-oxazole 

Relevant academic research and scientific papers

Singlet oxygen in synthesis. Oxazoles as carbonyl 1,1-dipole synthons

2,5-Diphenyloxazole has been utilized in a two-step sequence as a carbonyl 1,1-dipole synthon as illustrated by the synthesis of 7-heptanolide, α-benzyloxy δ-valerolactone, and 9-nonanolide. Alkylation of 4-lithio-2,5-diphenyloxazole, followed by singlet oxygen oxidation yields a triamide which undergoes cyclization to the lactone.