145914-05-2Relevant articles and documents
Synthesis of trifluoromethylated compounds from alcohols via alkoxydiphenylphosphines
Li, Jun-Li,Yang, Xian-Jin,Wang, Yanan,Liu, Jin-Tao
supporting information, p. 254 - 259 (2015/09/02)
The transformation of hydroxyl group in benzyl or allyl alcohols to trifluoromethyl was achieved via the reaction of the corresponding alkyloxydiphenylphosphine and CuCF3, generated in situ from methyl fluorosulfonyldifluoroacetate and CuI, under mild conditions. A plausible mechanism was proposed on the basis of experimental results.
The reactions of copper-dibromodifluoromethane-amide systems with alcohols
Clark, James H.,McClinton, Martin A.,Blade, Robert J.
, p. 257 - 267 (2007/10/02)
1,1,1-Trifluoro-2-arylethanes can be prepared by the trifluoromethyldehydroxylation of benzyl alcohols using the copper-dibromodifluoromethane-amide reaction system, although the yields are low.The mechanism of the reaction may involve chelation of the substrate to copper so that α-substituted benzyl alcohols and other alcohols are unreactive.